Dr. Gillian Hamilton

Dr. Gillian Hamilton is a Postdoctoral research fellow in the Rhodes lab with an interest in how various intrinsic and extrinsic factors, such as exercise and drugs of abuse, can affect hippocampal plasticity. She received her Ph.D in the Fall of 2012 from the University of Delaware under the mentorship of Dr. Anna Klintsova. During her time in graduate school, she worked with a rodent model of fetal alcohol spectrum disorders where she investigated the long-term impact of a third trimester alcohol exposure on both mPFC Layer II/III dendritic morphology and also on hippocampal adult neurogenesis and dentate gyrus granule cell morphology. In addition, she studied whether an intervention of wheel running alone or wheel running followed by environmental complexity could alleviate the alcohol-induced deficits in both the mPFC and the hippocampus. Currently, she is examining the role of adult neurogenesis on hippocampal dependent tasks through the use of a transgenic mouse model.

 

Publications

 

1. Hamilton, GF, Whitcher, LT & Klintsova, AY. 2010. Postnatal binge-like alcohol exposure decreases dendritic complexity while increasing the density of mature Spines in mPFC layer II/III pyramidal neurons. Synapse 64: 127-135.

 

2. Hamilton, GF, Murawski NJ, St. Cyr, SA, Jablonski, SA, Schiffino, FL, Stanton, ME, Klintsova, AY. 2011. Neonatal alcohol exposure disrupts hippocampal neurogenesis and contextual fear conditioning in adult rats. Brain Research 1412: 88-101.

 

3. Hamilton, GF, Boschen, KE, Goodlett, CR, Greenough, WT & Klintsova, AY. 2012. Housing in Environmental Complexity Following Wheel Running Augments Survival of Newly-Generated Hippocampal Neurons in a Rat Model of Binge Alcohol Exposure during the Third Trimester Equivalent. Alcoholism: Clinical and Experimental Research 36(7):1196-204.

 

4. Klintsova AY, Hamilton GF, Boschen KE. 2013. Long-term consequences of developmental alcohol exposure on brain structure and function: therapeutic benefits of physical activity. Brain Sciences 3(1):1-38.

 

5. Ortiz JB, McLaughlin KJ, Hamilton GF, Baran SE, Campbell AN, Conrad CD. 2013. Cholesterol and perhaps estradiol protect against corticosterone-induced hippocampal CA3 dendritic retraction in gonadectomized female and male rats. Neuroscience 246:409-21.

 

6. Hamilton, GF, Jablonski, SA, Schiffino, FL, St. Cyr, SA, Stanton, ME, & Klintsova, AY. 2014. Exercise and Environment as an Intervention for Neonatal Alcohol Effects on Hippocampal Adult Neurogenesis and Learning. Neuroscience 18;256-274-90.

 

7. Boschen, K.E., Hamilton, G.F., Delorme, J.E., and Klintsova, A.Y. 2014. Activity and social behavior in a complex environment in rats neonatally exposed to alcohol. Alcohol 48(6):533-41.

 

8. Hamilton, G.F., Majdak, P., Miller, D.S., Bucko, P.J., Merritt, J.R., Krebs, C.P., and Rhodes, J.S. 2015. Evaluation of a C57BL/6J x 129S1/SvImJ hybrid nestin-thymidine kinase transgenic mouse model for studying exercise-induced adult hippocampal neurogenesis. Brain Plasticity 83-95.

 

9. Hamilton G.F. and Rhodes J.S. 2015. Exercise Regulation of Cognitive Function and Neuroplasticity in the Healthy and Diseased Brain. Prog Mol Biol Transl Sci 135:381-406.

 

10. Hamilton G.F., Criss K.J., Klintsova A.Y. 2015. Voluntary exercise partially reverses neonatal alcohol-induced deficits in mPFC layer II/III dendritic morphology of male adolescent rats. Synapse 69(8):405-15.

 

11. Hamilton, G.F. and Rhodes, J.S. (2015) Animal models of Exercise-Brain Interactions. McMorris T (Eds.), Exercise-Cognition Interaction: Neuroscience Perspectives. Elsevier Science.

 

 

Links

 

Beckman Institute 2014 Postdoctoral Fellows

 

Hamilton Examines Natural Remedies to Fetal Alcohol Exposure

 

 

 

Last Modified: February 23rd, 2017

Designed by T.K. Bhattacharya and Petra Majdak

Curated by: Heinrich Pinardo

The Rhodes' Laboratory