Dr. Catarina Rendeiro
Dr. Catarina Rendeiro joined the Rhodes lab as a post-doctoral Research Associate. She did her undergraduate and MSc degrees in Biological Engineering at University of Lisbon and obtained her PhD in 2011 from University of Reading in the UK under the supervision of Professor Jeremy P.E. Spencer and Dr. Claire Williams. Catarina has been mainly interested in the beneficial effects of a class of compounds called flavonoids, widely found in fruits and vegetables, in different aspects of health. During her PhD, she investigated the effects of flavonoids on memory and learning in both aged and young animal models and she has been particularly interested in establishing the mechanisms by which this class of compounds can regulate brain function and enhance different aspects of synaptic plasticity. During her post-doctoral position at the Nutrition Department at the University of Reading, Catarina extended her research interests to the vascular aspects of flavonoid actions in human health. In particular, she has been involved in several human clinical trials investigating the impact of dietary flavanones and anthocyanins on human vascular function by assessing endothelial-dependent vasodilation using flow-mediated dilatation (FMD) of the brachial artery. Currently, Catarina is working in collaboration with the Center for Nutrition, Learning and Memory looking at impact of various nutritional interventions in memory, learning and cognitive function in rodent models.
1. Rendeiro, C., Dong, H., Saunders, C., Harkness, L., Blaze, M., Hou, Y., Belanger, R.L., Corona, G., Lovegrove, J.A. and Spencer, J.P.E. (2016). Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study. British Journal of Nutrition 116(12): 1999–2010.
2. Dong, H., Rendeiro, C., Kristek, A., Sargent, L.J., Saunders, C., Harkness, L., Rowland, I., Jackson, K.G., Spencer, J.P.E., and Lovegrove, J.A. (2016). Addition of Orange Pomace to Orange Juice Attenuates the Increases in Peak Glucose and Insulin Concentrations after Sequential Meal Ingestion in Men with Elevated Cardiometabolic Risk. The Journal of Nutrition 146(6): 1197-1203.
3. Rendeiro, C., Sheriff, A., Bhattacharya, T.K., Gogola, J.V., Baxter, J.H., Chen, H., Helferich, W.G., Roy, E.J., Rhodes, J.S. (2016). Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer. Behavioural Brain Research. 315:10-22.
4. Rendeiro, C., Masnik, A.M., Mun, J.G., Du, K., Clark, D., Dilger, R.N., Dilger, A.C., and Rhodes, J.S. (2015). Fructose decreases physical activity and increases body fat without affecting hippocampal neurogenesis and learning relative to an isocaloric glucose diet. Scientific Reports.
5. Rendeiro C, Foley A, Ring R, Lau V,Vauzour D, Regan C, Williams CM and Spencer JPE. (2014). A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats. Neuropharmacology. 79: 335-344.
6. Rendeiro C, Williams CM, Vauzour D, Rattray M, Butler LT, Wafo-Téguo P, Mérillon JM, and Spencer JPE. (2013). Pure flavonoids mediate improvements in spatial memory and increases in hippocampal brain-derived neurotrophic factor (BDNF). PLoS One. 28;8(5):e63535
7. Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, Spencer JPE. (2013). Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr. 98(5):1179-91.
8. Rendeiro C, Vauzour D, Kean RJ, Ellis JA, Butler LT, Rattray M, Spencer JPE and Williams CM. (2012). Blueberry-supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young animals. Psychopharmacology (Berl) 223(3): 319-330
9. Rendeiro C, Guerreiro JDT, Williams CM and Spencer JPE (2012). Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects. Proc Nutr Soc 71(2): 246-262.
10. Vauzour D, Vafeiadou K, Rendeiro C, Corona G and Spencer JPE (2010). The inhibitory effects of berry-derived flavonoids against neurodegenerative processes. Journal of Berry Research 1–8.
11. Rendeiro C, Spencer JP, Vauzour D, Butler LT, Ellis JA, and Williams CM. (2009). The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms". Genes Nutr. 4(4): 251–270.
12. Spencer JPE, Vauzour D, and Rendeiro C. (2009). Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects. Arch Biochem Biophys. 492(1-2):1-9.
13. Williams CM, El Mohsen MA, Vauzour D, Rendeiro C, Butler LT, Ellis JA, Whiteman M, Spencer JPE. (2008). Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med. 45(3):295-305.
14. Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JPE. (2008). The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr. 3(3-4):115-26.
15. Meireles M, Marques C, Norberto S, Fernandes I, Mateus N, Rendeiro C, Spencer JPE, Faria A, and Calhau C. (2015). The impact of chronic blackberry intake on the neuroinflammatory status of rats fed a standard or high-fat diet. Journal of Nutritional Biochemistry.
16. Rendeiro C, Rhodes JS, and Spencer JPE. (2015). The mechanisms of action of flavonoids in the brain: Direct versus indirect effects. Neurochemistry International.
Last Modified: February 23rd, 2017
Designed by T.K. Bhattacharya and Petra Majdak
Curated by: Heinrich Pinardo
The Rhodes' Laboratory